Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells.
Identifieur interne : 000A26 ( Main/Exploration ); précédent : 000A25; suivant : 000A27Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells.
Auteurs : Lijun Liang [République populaire de Chine] ; Kaiyuan Hui [République populaire de Chine] ; Chenxi Hu [République populaire de Chine] ; Yixuan Wen [République populaire de Chine] ; Shikun Yang [République populaire de Chine] ; Panrong Zhu [République populaire de Chine] ; Lei Wang [République populaire de Chine] ; Youyou Xia [République populaire de Chine] ; Yun Qiao [République populaire de Chine] ; Wen Sun [République populaire de Chine] ; Jiayan Fei [République populaire de Chine] ; Ting Chen [République populaire de Chine] ; Fenghua Zhao [République populaire de Chine] ; Baocheng Yang [République populaire de Chine] ; Xiaodong Jiang [République populaire de Chine]Source :
- Journal of experimental & clinical cancer research : CR [ 1756-9966 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Autophagie (), Carcinome pulmonaire non à petites cellules (anatomopathologie), Carcinome pulmonaire non à petites cellules (génétique), Carcinome pulmonaire non à petites cellules (traitement médicamenteux), Facteur de croissance endothéliale vasculaire de type A (génétique), Humains, Indoles (pharmacologie), Indoles (usage thérapeutique), Kinase Janus-2 (génétique), Lignée cellulaire tumorale, Modèles animaux de maladie humaine, Prolifération cellulaire, Quinoléines (pharmacologie), Quinoléines (usage thérapeutique), Souris, Souris nude, Tests d'activité antitumorale sur modèle de xénogreffe, Transduction du signal, Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (génétique), Tumeurs du poumon (traitement médicamenteux).
- MESH :
- anatomopathologie : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- génétique : Carcinome pulmonaire non à petites cellules, Facteur de croissance endothéliale vasculaire de type A, Kinase Janus-2, Tumeurs du poumon.
- pharmacologie : Indoles, Quinoléines.
- traitement médicamenteux : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- usage thérapeutique : Indoles, Quinoléines.
- Animaux, Autophagie, Humains, Lignée cellulaire tumorale, Modèles animaux de maladie humaine, Prolifération cellulaire, Souris, Souris nude, Tests d'activité antitumorale sur modèle de xénogreffe, Transduction du signal.
English descriptors
- KwdEn :
- Animals, Autophagy (drug effects), Carcinoma, Non-Small-Cell Lung (drug therapy), Carcinoma, Non-Small-Cell Lung (genetics), Carcinoma, Non-Small-Cell Lung (pathology), Cell Line, Tumor, Cell Proliferation, Disease Models, Animal, Humans, Indoles (pharmacology), Indoles (therapeutic use), Janus Kinase 2 (genetics), Lung Neoplasms (drug therapy), Lung Neoplasms (genetics), Lung Neoplasms (pathology), Mice, Mice, Nude, Quinolines (pharmacology), Quinolines (therapeutic use), Signal Transduction, Vascular Endothelial Growth Factor A (genetics), Xenograft Model Antitumor Assays.
- MESH :
- chemical , genetics : Janus Kinase 2, Vascular Endothelial Growth Factor A.
- chemical , pharmacology : Indoles, Quinolines.
- drug effects : Autophagy.
- drug therapy : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- genetics : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- pathology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- chemical , therapeutic use : Indoles, Quinolines.
- Animals, Cell Line, Tumor, Cell Proliferation, Disease Models, Animal, Humans, Mice, Mice, Nude, Signal Transduction, Xenograft Model Antitumor Assays.
Abstract
The efficacy and safety of multikinase inhibitor anlotinib have been confirmed in the treatment of advanced non-small cell lung cancer (NSCLC). However, the direct functional mechanisms of tumor lethality mediated by anlotinib were not fully elucidated, and the underlying mechanisms related to resistance remain largely elusive.
DOI: 10.1186/s13046-019-1093-3
PubMed: 30755242
Affiliations:
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Le document en format XML
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Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Hui, Kaiyuan" sort="Hui, Kaiyuan" uniqKey="Hui K" first="Kaiyuan" last="Hui">Kaiyuan Hui</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Chenxi" sort="Hu, Chenxi" uniqKey="Hu C" first="Chenxi" last="Hu">Chenxi Hu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Wen, Yixuan" sort="Wen, Yixuan" uniqKey="Wen Y" first="Yixuan" last="Wen">Yixuan Wen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Shikun" sort="Yang, Shikun" uniqKey="Yang S" first="Shikun" last="Yang">Shikun Yang</name><affiliation wicri:level="1"><nlm:affiliation>Hepatobiliary/Liver Transplantation Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hepatobiliary/Liver Transplantation Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029</wicri:regionArea><wicri:noRegion>210029</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Panrong" sort="Zhu, Panrong" uniqKey="Zhu P" first="Panrong" last="Zhu">Panrong Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Lei" sort="Wang, Lei" uniqKey="Wang L" first="Lei" last="Wang">Lei Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Xia, Youyou" sort="Xia, Youyou" uniqKey="Xia Y" first="Youyou" last="Xia">Youyou Xia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Qiao, Yun" sort="Qiao, Yun" uniqKey="Qiao Y" first="Yun" last="Qiao">Yun Qiao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Wen" sort="Sun, Wen" uniqKey="Sun W" first="Wen" last="Sun">Wen Sun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Fei, Jiayan" sort="Fei, Jiayan" uniqKey="Fei J" first="Jiayan" last="Fei">Jiayan Fei</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Ting" sort="Chen, Ting" uniqKey="Chen T" first="Ting" last="Chen">Ting Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Fenghua" sort="Zhao, Fenghua" uniqKey="Zhao F" first="Fenghua" last="Zhao">Fenghua Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Baocheng" sort="Yang, Baocheng" uniqKey="Yang B" first="Baocheng" last="Yang">Baocheng Yang</name><affiliation wicri:level="1"><nlm:affiliation>Jiangsu Provincial Institute of Health Emergency, Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Provincial Institute of Health Emergency, Xuzhou Medical University, Xuzhou, 221002, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Xiaodong" sort="Jiang, Xiaodong" uniqKey="Jiang X" first="Xiaodong" last="Jiang">Xiaodong Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu, China. jxdpaper@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, 222000, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of experimental & clinical cancer research : CR</title><idno type="eISSN">1756-9966</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Autophagy (drug effects)</term><term>Carcinoma, Non-Small-Cell Lung (drug therapy)</term><term>Carcinoma, Non-Small-Cell Lung (genetics)</term><term>Carcinoma, Non-Small-Cell Lung (pathology)</term><term>Cell Line, Tumor</term><term>Cell Proliferation</term><term>Disease Models, Animal</term><term>Humans</term><term>Indoles (pharmacology)</term><term>Indoles (therapeutic use)</term><term>Janus Kinase 2 (genetics)</term><term>Lung Neoplasms (drug therapy)</term><term>Lung Neoplasms (genetics)</term><term>Lung Neoplasms (pathology)</term><term>Mice</term><term>Mice, Nude</term><term>Quinolines (pharmacology)</term><term>Quinolines (therapeutic use)</term><term>Signal Transduction</term><term>Vascular Endothelial Growth Factor A (genetics)</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Autophagie ()</term><term>Carcinome pulmonaire non à petites cellules (anatomopathologie)</term><term>Carcinome pulmonaire non à petites cellules (génétique)</term><term>Carcinome pulmonaire non à petites cellules (traitement médicamenteux)</term><term>Facteur de croissance endothéliale vasculaire de type A (génétique)</term><term>Humains</term><term>Indoles (pharmacologie)</term><term>Indoles (usage thérapeutique)</term><term>Kinase Janus-2 (génétique)</term><term>Lignée cellulaire tumorale</term><term>Modèles animaux de maladie humaine</term><term>Prolifération cellulaire</term><term>Quinoléines (pharmacologie)</term><term>Quinoléines (usage thérapeutique)</term><term>Souris</term><term>Souris nude</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term><term>Transduction du signal</term><term>Tumeurs du poumon (anatomopathologie)</term><term>Tumeurs du poumon (génétique)</term><term>Tumeurs du poumon (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Janus Kinase 2</term><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Indoles</term><term>Quinolines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Facteur de croissance endothéliale vasculaire de type A</term><term>Kinase Janus-2</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Indoles</term><term>Quinoléines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Indoles</term><term>Quinolines</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Indoles</term><term>Quinoléines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Cell Proliferation</term><term>Disease Models, Animal</term><term>Humans</term><term>Mice</term><term>Mice, Nude</term><term>Signal Transduction</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Autophagie</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Modèles animaux de maladie humaine</term><term>Prolifération cellulaire</term><term>Souris</term><term>Souris nude</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The efficacy and safety of multikinase inhibitor anlotinib have been confirmed in the treatment of advanced non-small cell lung cancer (NSCLC). However, the direct functional mechanisms of tumor lethality mediated by anlotinib were not fully elucidated, and the underlying mechanisms related to resistance remain largely elusive.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liang, Lijun" sort="Liang, Lijun" uniqKey="Liang L" first="Lijun" last="Liang">Lijun Liang</name></noRegion><name sortKey="Chen, Ting" sort="Chen, Ting" uniqKey="Chen T" first="Ting" last="Chen">Ting Chen</name><name sortKey="Fei, Jiayan" sort="Fei, Jiayan" uniqKey="Fei J" first="Jiayan" last="Fei">Jiayan Fei</name><name sortKey="Hu, Chenxi" sort="Hu, Chenxi" uniqKey="Hu C" first="Chenxi" last="Hu">Chenxi Hu</name><name sortKey="Hui, Kaiyuan" sort="Hui, Kaiyuan" uniqKey="Hui K" first="Kaiyuan" last="Hui">Kaiyuan Hui</name><name sortKey="Jiang, Xiaodong" sort="Jiang, Xiaodong" uniqKey="Jiang X" first="Xiaodong" last="Jiang">Xiaodong Jiang</name><name sortKey="Qiao, Yun" sort="Qiao, Yun" uniqKey="Qiao Y" first="Yun" last="Qiao">Yun Qiao</name><name sortKey="Sun, Wen" sort="Sun, Wen" uniqKey="Sun W" first="Wen" last="Sun">Wen Sun</name><name sortKey="Wang, Lei" sort="Wang, Lei" uniqKey="Wang L" first="Lei" last="Wang">Lei Wang</name><name sortKey="Wen, Yixuan" sort="Wen, Yixuan" uniqKey="Wen Y" first="Yixuan" last="Wen">Yixuan Wen</name><name sortKey="Xia, Youyou" sort="Xia, Youyou" uniqKey="Xia Y" first="Youyou" last="Xia">Youyou Xia</name><name sortKey="Yang, Baocheng" sort="Yang, Baocheng" uniqKey="Yang B" first="Baocheng" last="Yang">Baocheng Yang</name><name sortKey="Yang, Shikun" sort="Yang, Shikun" uniqKey="Yang S" first="Shikun" last="Yang">Shikun Yang</name><name sortKey="Zhao, Fenghua" sort="Zhao, Fenghua" uniqKey="Zhao F" first="Fenghua" last="Zhao">Fenghua Zhao</name><name sortKey="Zhu, Panrong" sort="Zhu, Panrong" uniqKey="Zhu P" first="Panrong" last="Zhu">Panrong Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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